Western blot analysis showed upregulation of p53, p21, γ-H2AX and the NF-κB inhibitor Iκβα, and downregulation of the proliferation markers PCNA, NF-κB (p65), and p-MEK in tumor tissues of TQ-treated mice (Figure 6A), similar to in vitro 3D results. Here, MAP2K7 is linked to neoplasm.