BLMH and amyotrophic lateral sclerosis: Analysis of the EV proteome yielded good proteomic depth, with over 1200 protein groups identified, though the list of candidate markers identified that were differentially abundant between ALS and healthy controls, using a FDR threshold of 10% and log2 fold change of 0.5 was small: just one protein, BLMH, when considering only first-visit ALS samples.