LAP3 and amyotrophic lateral sclerosis: Similarly, overrepresentation analysis (Fig. 6c and Additional file 1: Table S4) identified GO terms related to the proteasome (e.g. “peptidase activity, acting on L-amino acid peptides”, 7/97 proteins, odds ration − 4.44, FDR-adjusted p = 0.068; “carboxypeptidase activity” 3/13 proteins, OR − 14.21, FDR-adjusted p = 0.068; “proteasome core complex” 3/13 proteins, OR − 14.21, FDR-adjusted p = 0.100) as well as terms related to keratinisation (e.g. “keratinization”, 8/61 proteins, OR − 8.18, FDR-adjusted p = 0.004) in proteins downregulated in ALS.