Although analysis in C9orf72-expansion associated ALS yielded more significant proteins at the 10% FDR level, these were of low fold change and GO enrichment analysis demonstrated limited systematic changes in the proteome, predominantly hinting at differences in synaptic membrane proteins between C9orf72 and non-C9orf72 ALS. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.