All proteins in the proteomic dataset encoded by genes annotated to the cellular component term “proteasome core complex” i.e. proteasomal alpha (PSMA4 UniProt P25789; PSMA5, P28066; PSMA6, P60900; PSMA7, O14818) and beta subunits (PSMB1, P20618; PSMB2, P49721; PSMB3, P49720; PSMB6, P28072), had negative log fold change in ALS compared with healthy controls (Fig. 6d). The gene discussed is PSMB2; the disease is amyotrophic lateral sclerosis.