SOX4 and cholangiocarcinoma: Earlier studies showed that KCNQ1OT1 promoted NSCLC progression by modulating miRNA-27b-3p/HSP90AA1 axis [23], and stimulated cholangiocarcinoma development via miR-140-5p/SOX4 axis [47], and facilitated the migration and EMT of colorectal cancer by forming a feedback loop with miR-217 and ZEB1 [48].