KCNQ1OT1 and pachyonychia congenita: Considering that KCNQ1OT1 promoted the progression and metastasis of various cancers [24, 26], and was up-regulated in PC tissues, and negatively correlated with miR-15a level (Fig. 1), we examined its regulation on miR-15a and the functional significance of KCNQ1OT1/miR-15a axis.