KCNQ1OT1 and pachyonychia congenita: Yet we identified that the lncRNA KCNQ1OT1 suppressed miR-15a expression in PC cells, not only their expressions negatively associated with each other in human PC tissues, but also KCNQ1OT1 directly bound to miR-15a and was sufficient and necessary to inhibit endogenous miR-15a level in PC cells.