Earlier studies showed that KCNQ1OT1 promoted NSCLC progression by modulating miRNA-27b-3p/HSP90AA1 axis [23], and stimulated cholangiocarcinoma development via miR-140-5p/SOX4 axis [47], and facilitated the migration and EMT of colorectal cancer by forming a feedback loop with miR-217 and ZEB1 [48]. The gene discussed is SOX4; the disease is colorectal cancer.