Our data showed that the overexpression of PRRX1 could reverse the decrease of cyclin D1 and c‐Myc caused by FASN silencing in vitro, and the expressions of cyclin D1 and c‐Myc were down‐regulation when PRRX1 reduced in FASN‐shRNA xenograft tumours. The gene discussed is CCND1; the disease is neoplasm.