Various studies indicate that leptin is an important pro-inflammatory mediator in different tissues of the dentoalveolar system: High levels of this adipokine were detected in infected dental pulps and in periapical granulomas [23], and it is well known that increased levels of leptin in saliva and in crevicular fluids, common in individuals with a high white fat mass, elevate the risk for periodontal disease development [24–26]. This evidence concerns the gene LEP and periapical granuloma.