In support of the known role of PLA2G2A, we found an increase in the inclusion of exon-2 in advPC in comparison to CRPC (paired and unpaired samples), BPH in comparison to L.PC (unpaired samples) and in response to the pharmacological or genomic inhibition of AR signaling in LNCaP and MDA-PCa-2b cell lines, respectively (Fig. 5c). Here, AR is linked to posterior cortical atrophy.