Protein misfolding causing assembly and amyloid fibril aggregation is a huge matter in many human neurodegenerative diseases1,2: in particular Tau protein which is one of the major players in Alzheimer disease (AD), Pick’s disease, Chronic Traumatic Encephalopathy (CTE), Parkinson’s disease, and Progressive Supranuclear Palsy (PSP)3. This evidence concerns the gene MAPT and Alzheimer disease.