Besides, searching for associations between subclass profile against PvCSP-variants and epidemiological data, we identified that the number of previous malaria episodes positively correlated with the IgG1 levels to PvCSP-VK210 (p = 0.008, r = 0.204) and IgG3 levels to PvCSP-VK247 (p = 0.0007, r = 0.278). The gene discussed is IGHG3; the disease is malaria.