Moreover, in places where malaria is endemic and the local population has had several malaria episodes through the years, there are evidences that the premonition (immune condition characterizing clinical protection as reflected by the absence of fever and presence of infection at low densities of parasitemia) is reached after repeated infections, due to the presence of both cytophilic antibodies (IgG1 and IgG3) and memory cells41–43. The gene discussed is IGHG3; the disease is malaria.