CD53 and neoplasm: Moreover, we present a strategy for specifically exploiting this bivalent antigen recognition in a controlled manner, ultimately opening up a range of applications in which an AvidCAR integrates multiple input signals, e.g., (1) a cell surface antigen and a clinically applied small molecule, (2) two different cell surface antigens and a small molecule or (3) a cell surface antigen and a soluble factor enriched in the tumor microenvironment.