PBRM1 and cancer: PBRM1 mutations were not significantly associated with OS in a cohort of 11 cancer types in a Cox model stratified by cancer type (LOF HR = 0.9, 95% CI 0.6,1.4, p = 0.7; non-LOF HR 1.03, 95% CI 0.73,1.5, p = 0.86), and remained insignificant after adjusting for TMB and total CNA (LOF HR = 1.2, 95% CI 0.8,1.81, p = 0.37; non-LOF HR = 1.32, 95% CI 0.92,1.9, p = 0.13) (Supplementary Table 1).