PBRM1 mutations were not associated with TTF in the entire ccRCC cohort (LOF HR 0.73, p = 0.11; non-LOF HR 1.05, p = 0.84) and not significantly associated with OS (LOF HR = 1.5, p = 0.16; non-LOF HR = 1.05, p = 0.91) (Table 3). This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.