PBRM1 and nonpapillary renal cell carcinoma: We are ultimately unable to demonstrate a favorable response to ICB in patients with PBAF complex mutations and further, gene-expression analysis of PBRM1 mutated metastatic ccRCC patients demonstrate consistent upregulation in hypoxia inducible factor (HIF) signaling and angiogenesis, but inconsistent interferon gamma signaling and other immune response pathways.