PRKCI and lung cancer: ATM and ANF were previously reported to block atypical PKC signaling by blocking the interaction between atypical PKCs and Par6, Ect2, or p6210,22 while Oncrasin-1 was found to only induce cell death in the presence of both mutant K-Ras and PKCι.23 However, MTT assay showed that the IC50 values calculated for ATM and Oncrasin were quite high compared to the published values for lung cancer.