EpCAM-siPKCι aptamer-led cell growth reduction in PRKCI-amplified ovarian cancer cells was clearly caused by apoptosis as we detected apparent cleavage of PARP and CASP3 after 3-day treatment in SK-OV-3 and OCC1 but not in the OVCAR-8 cell line (Fig. 5d). Here, CASP3 is linked to ovarian carcinoma.