Furthermore, we observed that YKL-40 overexpression significantly prolonged the overall survival of nude mice implanted with WZ05 Y+ GSCs while knockdown of YKL-40 shortened the overall survival of nude mice implanted with WZ28 Y− and WZ29 Y− GSCs (Fig. 2g, left), suggesting a inhibitory role of YKL-40 in tumor initiation or progression in these GSCs (WZ05 vs. WZ05 Y+ P = 0.019; WZ28 vs. WZ28 Y− P = 0.004; WZ29 vs. WZ29 Y− P = 0.02). The gene discussed is CHI3L1; the disease is neoplasm.