We found that lncRNA-TTN-AS1 upregulates actin-binding protein fascin homolog 1 (FSCN1) by sponging miR-133b, and combines directly with the mRNA-stabilizing protein HuR to stabilize FSCN1 mRNA, resulting in the epithelial-mesenchymal transition cascade in esophageal squamous cell carcinoma (ESCC)8. The gene discussed is ELAVL1; the disease is esophageal squamous cell carcinoma.