Using triple-negative breast cancer MDA-MB-231 cells stably expressing CASC4 or its selected mutants, we demonstrated that wild type (WT) CASC4 enhances cell adhesion by increasing the number of focal adhesions (FA) and actin stress fibers, and that its shedding by PC7/Furin abrogates this phenotype. This evidence concerns the gene FURIN and triple-negative breast carcinoma.