The cytoskeletal extensions observed upon overexpression of CASC4 in Hela cells (Fig. 1g), and the correlation between PCSK7-CASC4 mRNA levels with breast cancer patients’ survival (Fig. 3a, b) suggested that CASC4 may impact cell migration and invasion, two essential steps of the metastatic process. The gene discussed is GOLM2; the disease is breast cancer.