Mutations in WRN, BLM, or RECQL4 cause different genetic disorders, all associated with accelerated aging, genomic instability and tumorigenesis (Ellis et al, 1995; Yu et al, 1996; Kitao et al, 1999; Siitonen et al, 2003; Van Maldergem et al, 2006). Here, RECQL4 is linked to hereditary disease.