This hypothesis is supported by previous publications indicating that IRF4 or FOXM1 inhibition induces cell death and influences the proliferation in MM cell lines, although efficient strategies to block these TFs in MM patients are still missing (Shaffer et al. 2008; Morelli et al. 2015; Gu et al. 2016). The gene discussed is FOXM1; the disease is Miyoshi myopathy.