The results point to a variety of functions previously described to be altered in MM (Bommert et al. 2006; Hu and Hu 2018), including regulation of osteoblast differentiation, multiple signaling pathways, such as NF-kB signaling, MTOR signaling, the TP53 pathway, and the NOTCH pathway, as well as oxidative stress responses (Fig. 2E). Here, NFKB1 is linked to Miyoshi myopathy.