PRDM5 and Miyoshi myopathy: Out of these, we detected that genes down-regulated upon PRDM5 silencing were associated with the cell cycle as well as various types of cellular stress responses such as DNA damage stress induced by UV light and unfolded protein response stress, suggesting that PRDM5 may be involved in protecting MM cells against the cellular stress created by proliferation and high protein synthesis (Fig. 4H), although further functional validation is required.