TXN contributes to maintain reactive oxygen species (ROS) homeostasis in the cell to prevent oxidative damage (Arnér and Holmgren 2006) and has been recently shown to enhance cell growth in MM, and its inhibition leads to ROS-induced apoptosis in MM cell lines (Raninga et al. 2015; Sebastian et al. 2017). The gene discussed is TXN; the disease is Miyoshi myopathy.