These sites were enriched in binding motifs of IRF, FOX, and MEF2 transcription factor (TF) families (Fig. 2B; Supplemental Table S5), which have been previously linked to MM pathogenesis (Carvajal-Vergara et al. 2005; Shaffer et al. 2008; Campbell et al. 2010; Bai et al. 2017; Agnarelli et al. 2018). This evidence concerns the gene TRIM63 and Miyoshi myopathy.