TF and Miyoshi myopathy: We observed that the majority of these CpGs were hypomethylated in MM as compared to normal B cells (57%–74% of CpGs with methylation difference >0.25) (Fig. 2C; Supplemental Fig. S10) and that DNA methylation levels sharply decreased in TF binding regions as compared to surrounding areas (Fig. 2D; Supplemental Fig. S11).