Thus, the regulated expression of Bir1 with or without its C-terminal domain could potentially alter virulence traits or the rate of chromosomal aneuploidy (Ravichandran et al. 2018), which have been previously associated with acquisition of fluconazole resistance (Marichal et al. 1997) and host infection by C. glabrata (Poláková et al. 2009). Here, KCNJ6 is linked to infection.