In this study, based on three post-treatment serum markers (serum ferritin, platelets and ALT) extracted from 136 HLH patients, we developed a model to forecast the prognosis of HLH patients with all etiologies in six-month, which is different from one model for predicting the risk of 5-year overall survival in adult HLH patients not associated with malignancy. Here, GPT is linked to hemophagocytic syndrome.