In addition, we have analyzed public gene expression profiles of Down syndrome (blood; GSE35665, n = 15 [26]), Werner syndrome (fibroblasts; GSE48761, n = 10 [27]), and HGPS (fibroblasts; GSE69391, n = 6 [28] and GSE3860, n = 3 [29]), but none of these datasets revealed significant gene expression changes in PRDM8 (data not shown). Here, PRDM8 is linked to Down syndrome.