PRDM8 and premature aging syndrome: Notably, genome wide DNA methylation profiles of other premature aging syndromes provided similar hypermethylation within PRDM8 and hypomethylation in the promoter of the long transcript of PRDM8. In fact, one of the top 25 differentially methylated regions (DMRs) reported in Werner syndrome is located within PRDM8 [42].