Dex and other glucocorticoids are used to treat RA because they down-regulate secretion of pro-inflammatory cytokines such as IL-1β, TNF-α and IL-6 by activated macrophages at inflammation lesions, while up-regulating secretion of the anti-inflammatory cytokine IL-10 [10, 11, 19]. This evidence concerns the gene TNF and rheumatoid arthritis.