The strength of this study was the demonstration that oxytocin infusion reduced adipose tissue inflammation in an established mouse model of obesity, similar to the effects attributed to oxytocin in a variety of experimental inflammatory conditions [7, 11, 60–63] Limitations of this study include only the use of male mice so that sex differences, if any, were not evaluated. The gene discussed is OXT; the disease is obesity due to melanocortin 4 receptor deficiency.