Using a labeled miR-1246 probe as “bait”, we fished out several RBPs from pancreatic cancer cells, including serine and arginine rich splicing factor 1 (SRSF1), eukaryotic translation initiation factor 3 subunit B (eIF3B), and T cell-restricted intracellular antigen 1 (TIA1). The gene discussed is EIF3B; the disease is pancreatic neoplasm.