An immunologic mediated response issupported by several aspects like the presence of eosinophilia and high IgE levels,presence of specific IgE antibody to the common mosquito, as well as the clinicalpresentation, namely the severity of the relapse and the sustained remission afteravoidance of exposure, probably the longest described in literature. The gene discussed is IGHE; the disease is Increased total eosinophil count.