Thus, therapeuticinterventions for reducing proteinuria are suggested to slow the progression ofchronic kidney disease and the reduction in GFR.26 Several experimental studies have shown a positive associationbetween albuminuria and tubular MCP-1/CCL-2 expression.27,28 MCP-1/CCL-2, which is produced bymesangial and tubular epithelial cells, is expressed by activatedmonocyte/macrophages, T cells, and natural killer cells. Here, CCL2 is linked to kidney disorder.