SNP array and WGS data was generated from 67 paired normal/tumour samples from a familial breast cancer cohort, including carriers of pathogenic germline mutations in BRCA1 (n = 19) or BRCA2 (n = 20) and 28 tumours from high risk individuals from breast cancer families not attributed to BRCA1 or BRCA2 germline mutations (non-BRCA1/2)12. The gene discussed is BRCA2; the disease is breast carcinoma.