The ACE2-positive rate in oral cancer cells was 3.7% (75/2027) (Fig. 4b), while the ACE2-positive ratio in KYSE-180 treated with different doses of radiotherapy was, 4.88% (2/41) for 0 Gy, 14.13%(13/92) for 12 Gy, and 11.24% (10/89) for 30 Gy (Fig. 4c). The gene discussed is ACE2; the disease is lip and oral cavity carcinoma.