In this study, in order to find out IL-17’s exact function, we analyzed the transcriptome sequencing in ischemic cortex between WT and IL-17 KO mice, and the results showed that DEGs were enriched in some pathway, like cancer, TNF, PI3K/Akt, p53 and IL-17 pathway (Fig. 1 d, e). The gene discussed is TP53; the disease is cancer.