Interestingly, we noticed that 14 genes related to COL8A1 (WNT2, GADD45B, FZD2, CDKN1A, KRAS, LEF1, WNT7B, BAK1, BRCA2, CDK4, GRB2, HRAS, PIK3R3, and POLK) were associated with the breast cancer pathway (ID: hsa05224), even though this pathway is not in the top 30 KEGG signaling pathways. The gene discussed is CDK4; the disease is breast cancer.