ACE2 and COVID-19: The contrast between our observation that adipose tissue ACE2 levels were positively correlated with age -another strong risk factor for severe COVID-19-yet negatively correlated with COVID-19 cardio-metabolic risk factors may reflect the multi-systemic nature of COVID-19, and may indicate that the various COVID-19 risk factors, including age, may be mediated through different tissues and underlying mechanisms of susceptibility.