RAMP1 and migraine disorder: For example, the pain managing drug for migraine, the calcitonin gene-related peptide (CGRP) receptor antagonist, MK-0974, was found to be > 10 fold more potent in human and rhesus/marmoset monkeys than in rodents because of greater sequence homology in receptor activity modifying protein 1 (RAMP1), which combines with the calcitonin receptor-like receptor to act as a receptor for CGRP (Hershey et al., 2005, Salvatore et al., 2008).