KEGG pathway enrichment analysis revealed significant associations between several pathways and the pathogenesis of PV, including upregulation of the NOD-like receptor pathway, antigen processing and presentation, inflammatory bowel disease, the IL-17 pathway, and cytokine receptor interactions as well as downregulation of the PPAR pathway, fatty acid metabolism, cell adhesion molecules, and protein digestion and absorption. The gene discussed is PPARA; the disease is acquired polycythemia vera.