Besides, we also annotated some significant proteins which was closely associated with psoriasis, for example, MPO, TYMP, IMPDH2, ALDH3A2, GSTM4, S100A8/9, COX5A, CD40, HLA-A, FABP5, STAT1/2/3, IL-18, etc. Proteins with a differential expression between PV lesions and normal tissue can be considered as pathological biomarkers for therapeutic development. The gene discussed is CD40; the disease is acquired polycythemia vera.