KEGG pathway enrichment analysis revealed significant associations between several pathways and the pathogenesis of PV, including upregulation of the NOD-like receptor pathway, antigen processing and presentation, inflammatory bowel disease, the IL-17 pathway, and cytokine receptor interactions as well as downregulation of the PPAR pathway, fatty acid metabolism, cell adhesion molecules, and protein digestion and absorption. Here, IL17A is linked to acquired polycythemia vera.