We found an epitope (ID 742143) located on signal peptide, which showed high binding affinity to HLA-A*0201 molecules and frequencies of epitope-specific cytotoxic T lymphocytes in the peripheral blood mononuclear cells of patients with HFRS and could induce CD8+ T-cell responses to inhibit HTNV replication [41]. The gene discussed is HLA-A; the disease is hemorrhagic fever with renal syndrome.