It is probably that the alteration in microtubule proteins in the taiep rats was recently had been proposed as a tubulinopathy with a point mutation in the beta tubulin 4A (TUBB4A) similar to human hypomyelination with atrophy of basal ganglia and cerebellum (H-ABC) one of the leukodystrophies [31], and myelin decrease could cause protection against the infection with the human nematode Trichinella spiralis. Here, TUBB4A is linked to leukodystrophy.