Interestingly, phosphatidylinositol 3-kinase catalytic subunit type 3 was upregulated at 48h p.i., while phosphatidylinositol 3-kinase regulatory subunit beta was downregulated, suggesting that the PI3K/A cascade is activated following ZIKV infection (S3 Fig). Here, PIK3R2 is linked to Zika virus infectious disease.