In our study, carrying at least one APOE ε4 allele was associated with a 5.9 (5.3–6.6; p < 0.001) higher OR of AD, compared with an OR of 3.3 (3.2–3.4; p < 0.001) reported by a recent meta-analysis of 46 case–control studies with 64,000 participants [31]. The gene discussed is APOE; the disease is Alzheimer disease.