APOE and Alzheimer disease: Therefore, the present study aims to examine the global and age-specific association of APOE status with AD risk using a case–control design based on data on AD cases from nine European memory centers and the American Alzheimer’s Disease Neuroimaging Initiative (ADNI) study [18], in which diagnosis were based both on clinical criteria [16] and on positive-biomarkers profile according to A/T/N classification [17].