The association of APOE ε4 genotype with AD was modified by age (p for interaction with age2 < 0.001), with the strongest association in the 65–70 age group: one ε4 allele (OR: 10.7 [7.6–15.2]; p < 0.001), ε4/ε4 (OR: 64.2 [34.1–120.8]; p < 0.001). Here, APOE is linked to Alzheimer disease.