ADAMTS2 and Stroke: The non-synonymous called variants identified in our applied NGS approach on 48 discordant sib-pairs for ADAMTS2 and ADAMTS12 and not implemented on the previously used array for genome-wide genotyping [1] (rs1054480, rs398829 ADAMTS2; rs25754, rs3813474 ADAMTS12) were forwarded to validation in the full cohort of 270 affected offspring trios for pediatric stroke already applied in our former GWAS study [1] and subsequent family-association testing using TDT (see Table 1).