CD8A and infection: Similarly, our model predicts that suppression of effectors due to anti-CD8 Abs up to a threshold after the establishment of control allowed resurgence in viremia but restored control, whereas suppression beyond the threshold sacrificed control and drove infection to the former, high viremic fate (Fig 2), explaining the difference between the controller macaques who reasserted viremic control following the transient rise in viremia upon the administration of anti-CD8 Abs and the one controller macaque (DFIK) that failed to reassert control and transitioned to the high viremic state [10].