TLR8 and infection: Although WT infection-specific regulation was observed only for TLR8 and IFNGR1, all four genes were expressed at higher levels (TLR8 and TLR9) or at lower levels (IFNGR1 and PYCARD) in the WT-infected dTHP1 cells than in the mock-treated or ΔrtxA1 mutant-infected dTHP-1 cells (Fig. S3B).