AKT1 and neoplasm: The mTOR pathway integrates spatiotemporal information of the tumor growth including apoptosis, autophagy, cell metabolism, and immune responses.36 For example, the mTOR signaling is an important pathway for regulating macrophage polarization and NK cells activity,43 44 primarily via the PI3K/Akt/mTOR axis.45 Therefore, it plays a central role in regulating tumor microenvironment.