HIF1A and cancer: Of note, mTOR plays an essential role in cancer metabolism; for example, mTOR signaling controls glucose metabolism by upregulating glycolytic enzymes and glucose transporters and activating the transcription factors (eg, HIF-1α).36 Our work demonstrated that the inhibition of Akt/mTOR signaling promoted autophagy and the repolarization of TAM (M2→M1), as well as repressed glucose metabolism and lactic acid production, thus regulating the populations of the immune cells and the expression of cytokines.