Although this is consistent with observations that T cell effector function may be restricted when uptake of nutrients (such as glucose) and generation of glycolytic metabolites falls below a threshold (13, 14), our results also showed that Ag-expT-bet+ Th1 cells exhibited a substantial loss of effector function at the later stages of malaria despite sustaining mTOR pathway activity. The gene discussed is MTOR; the disease is malaria.