CD4 and infection: Phosphorylation of S6 and 4EBP1 (associated with mTORc1 activity) and AKT473 (associated with mTORc2 activity) was observed on day 5 of infection in CD4+ T cells from WT littermates but not from mTORΔ/Δ animals, indicating that the mTORc1 and mTORc2 pathways were activated in WT CD4+ T cells during the initiation of the immune response during malaria infection (Fig. 1A).