MYC and infection: However, the expression of these molecules was not maintained, and in parallel with the loss of effector function, Ag-expCD4+ T cells on day 15 of infection exhibited significantly reduced activation of pS6, p4EBP1, pAKT473, and c-Myc compared with Ag-expCD4+ T cells on day 5 of infection (Fig. 2C, 2D).