Interestingly, the inactivation of Snf5-related 1 (Snr1), the Drosophila ortholog of human SMARCB1 (inactivation of which causes ATRTs), in type II NBs also causes aggressive tumors, showing that the tumor-suppressive activity of Snr1/SMARCB1 in neural progenitors is conserved throughout evolution (Eroglu et al., 2014; Koe et al., 2014). The gene discussed is SMARCB1; the disease is neoplasm.