In contrast, the canonical pathway analysis revealed that the DEGs that were only found in the AD mouse hippocampus were involved in “dendritic cell maturation,” “altered T cell and B cell signaling in rheumatoid arthritis,” and “communication between innate and adaptive immune cells.” The top upstream regulators included L2HGDH, lipopolysaccharide (activated), TBX5, FOSL1, and CR1L. Here, L2HGDH is linked to rheumatoid arthritis.