L2HGDH and Alzheimer disease: In contrast, the canonical pathway analysis revealed that the DEGs that were only found in the AD mouse hippocampus were involved in “dendritic cell maturation,” “altered T cell and B cell signaling in rheumatoid arthritis,” and “communication between innate and adaptive immune cells.” The top upstream regulators included L2HGDH, lipopolysaccharide (activated), TBX5, FOSL1, and CR1L.