According to our previous results, DIM protects hippocampal neurons against hypoxia and ischemia in vitro through the inhibition of proteins in the AhR signaling pathway, including AhR, ARNT and CYP1A1 [6, 7] which is in line with our present in vivo results i.e., the downregulation of AhR signaling in DIM-treated rats subjected to birth asphyxia. Here, AHR is linked to asphyxia.