The finding that increasing variation in retinal thickness was adversely associated with BCVA and the risk of developing fibrosis and GA provides an impetus to seek agents with greater treatment durability or sustained release devices, such as those currently undergoing evaluation.5 In summary, the findings of the present analyses are clinically important with respect to prognosis in nAMD and offer insights into key functional and morphological outcomes in patients with nAMD undergoing treatment anti-VEGF agents. The gene discussed is VEGFA; the disease is fibrosis.