In Control Family 5, while the 30-years-old proband had no HCM or left ventricular hypertrophy, the 57-year-old father who also has the TNNI3:p.R79C variant was diagnosed with HCM with patchy fibrosis during screening as part of this study (Figure IIIB in the Data Supplement). Here, TNNI3 is linked to left ventricular hypertrophy.