Interestingly, in one family the younger proband was compound heterozygous for TNNI3:p.R79C and TNNT2:p.R286H and had more severe left ventricular hypertrophy (20 mm) as compared to his elder sibling, who had the TNNI3:p.R79C variant only and relatively smaller LVMWT (15 mm) despite the older age (Figure IIIA in the Data Supplement). Here, TNNT2 is linked to left ventricular hypertrophy.