Then, the results of univariate and multivariate analysis with the 27 prognosis‐related genes were performed, and nine independent prognostic factors (PTHLH, PLXNA3, BIRC5, FOS, DKK1, FGF13, IL11, IL17D, SPP1) of HCC were extracted according to the results of univariate and multivariate analysis (Table 1). The gene discussed is BIRC5; the disease is hepatocellular carcinoma.