In univariate analysis, we could see that risk scores calculated from the signature (HR 1.169, 95%CI 1.071‐1.277, P < .001), stage (HR 1.344, 95%CI 1.048‐1.722, P = .020), age (HR 1.796, 95%CI 1.111‐2.903, P = .017), HBV infection (HR 0.464, 95%CI 0.274‐0.785, P = .004), and AFP (HR 1.632, 95%CI 1.014‐2.627, P = .044) were connected with OS of HCC patients(Figure 3O). This evidence concerns the gene AFP and hepatocellular carcinoma.