SPP1 and hepatocellular carcinoma: Then, the results of univariate and multivariate analysis with the 27 prognosis‐related genes were performed, and nine independent prognostic factors (PTHLH, PLXNA3, BIRC5, FOS, DKK1, FGF13, IL11, IL17D, SPP1) of HCC were extracted according to the results of univariate and multivariate analysis (Table 1).