Similar with TBX6, biallelic loss‐of‐function variants in RIPPLY2 or MESP2 cause autosomal recessive Spondylocostal Dysostosis (MIM#616566 for RIPPLY2 and MIM#608681 for MESP2). The gene discussed is MESP2; the disease is autosomal recessive spondylocostal dysostosis.