Other accepted genetic loci that connected with T1D risk have a minimal effect than HLA, confirmed by relative risk vary from odds ratio (OR) = 2.38 (11p155.5, insulin gene (INS)) to OR = 1.05 (17q21.2: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1)) [43–51]. Here, INS is linked to type 1 diabetes mellitus.