In turquoise gene module, the only gene module positively correlated with CRC, the top ranked hub genes were all verified to be expressed significantly highly in colon cancer compared with normal, including PAICS (P=1.62E-12), ATR (P<1E-12), AASDHPPT (P=1.62E-12), DDX18 (P<1E-12), NUP107 (P<1E-12) and TOMM6 (P<1E-12) (Figure 9). This evidence concerns the gene PAICS and colorectal carcinoma.