In the turquoise gene module, 20 hub genes were identified positively correlated with CRC, including PAICS, ATR, AASDHPPT, DDX18, NUP107, TOMM6, GTPBP4, RAN, GPN3, SYNCRIP, CPSF3, PTRH2, SSRP1, BZW2, NEMP1, PTPMT1, CCT6A, HEATR1, TRIM27 and MRPL17 (Figure 8). Here, PTRH2 is linked to colorectal carcinoma.