Nineteen hub genes in the blue gene module were identified negatively correlated with CRC, including DHDDS, ORC3, HIGD1A, GIPC1, CNNM4, UGDH, GLTP, EPB41L3, PTPRH, HSD11B2, ATG4A, C2orf88, CCDC68, TMPRSS2, TJP3, PKIB, MMP28 and GPA33. In the black gene module, IGLC1, MZB1, IGKV1OR2-108, DNASE1L3, IGLL5 and CPA3 were identified negatively correlated with CRC. Here, HSD11B2 is linked to colorectal carcinoma.