Nineteen hub genes in the blue gene module were identified negatively correlated with CRC, including DHDDS, ORC3, HIGD1A, GIPC1, CNNM4, UGDH, GLTP, EPB41L3, PTPRH, HSD11B2, ATG4A, C2orf88, CCDC68, TMPRSS2, TJP3, PKIB, MMP28 and GPA33. In the black gene module, IGLC1, MZB1, IGKV1OR2-108, DNASE1L3, IGLL5 and CPA3 were identified negatively correlated with CRC. This evidence concerns the gene MMP28 and colorectal carcinoma.