Nineteen hub genes in the blue gene module were identified negatively correlated with CRC, including DHDDS, ORC3, HIGD1A, GIPC1, CNNM4, UGDH, GLTP, EPB41L3, PTPRH, HSD11B2, ATG4A, C2orf88, CCDC68, TMPRSS2, TJP3, PKIB, MMP28 and GPA33. In the black gene module, IGLC1, MZB1, IGKV1OR2-108, DNASE1L3, IGLL5 and CPA3 were identified negatively correlated with CRC. The gene discussed is CPA3; the disease is colorectal carcinoma.