In addition to lamin, nesprin 2 and other LINC proteins, Sun1 and emerin, have been implicated to involve in the pathogenesis of progeria or EDMD of the laminopathies (Kandert et al, 2007; Zhang et al, 2007; Chen et al, 2012; Ho et al, 2013). The gene discussed is SYNE2; the disease is laminopathy.